Without knowing about your combination its difficult to make a suggestion.In most cases you run 2 sizes larger jets in the secondaries.
You may have blown powervalves and are sucking too much fuel into the engine and it cant burn it all.
Does your engine blow out black smoke at w.o.t.?If so you could try dropping the jets down 2 sizes and recheck it.Its safer to be a little rich than run it too lean and melt a valve or piston