Don't use a gear drive.
I would only use a gear drive for a drag application that I was doing on a budget. even now there is not that big of a gap between a gear drive and a belt drive costs.
The gear drives tranmit to much valve train harmonics down the the main and rod bearings. The end result is premature wear or failer of the rotating assembly.
I have used rooler chains for years up to 950hp and up to 700in of gross valve lift with out any failers. I can not atest to true hores power lost due to fluctuating cam timing but I have always made the numbers.
If you have the bigg bucks I would say use a belt drive..
Just my .02
Timmy