Moparjet,
I would suggest starting with a factory tune up in the carbs including the power valves. This will give you a good starting point you can build from.
Having the power valves blocked will make tuning the carbs at WOT easier, but this also means if you do alot of cruzing you will be way fat. Blocking the power valves is usually a race set up, you just need to decide what you can live with and how you plan on using the boat.
Good luck.